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</topic><topic id="https://vocabulario.abcd.usp.br/pt-br/?tema=1494"><instanceOf><topicRef xlink:href="#term"/></instanceOf><baseName><baseNameString>ADJUVANTES IMUNOLÓGICOS</baseNameString></baseName>  <occurrence>    <instanceOf>      <topicRef xlink:href="#scope-note"/>    </instanceOf><baseName><baseNameString><![CDATA[ Substâncias que aumentam, estimulam, ativam, potenciam ou modulam a resposta imune em nível celular ou humoral. Os agentes clássicos (adjuvante de Freund, BCG, Corynebacterium parvum, etc.) contêm antígenos bacterianos. Alguns são endógenos (p. ex., histamina, interferon, fator de transferência, tuftsina, interleucina-1). Seu modo de ação pode ser inespecífico (resultando em responsividade imune aumentada a uma ampla variedade de antígenos), ou específico para o antígeno (i.e., afetando um tipo restrito de resposta imune a um grupo reduzido de antígenos). A eficácia terapêutica de muitos modificadores de respostas biológicas está relacionada com a especificidade entre os imunoadjuvantes e os antígenos.<p>Fonte: DeCS. Disponível em: https://decs.bvsalud.org/ths/resource/?id=27905.<p> ]]></baseNameString></baseName>  </occurrence></topic>  <association>    <instanceOf>      <topicRef xlink:href="#broader-narrower"/>    </instanceOf>    <member>      <roleSpec>  <topicRef xlink:href="#narrower"/>      </roleSpec>      <topicRef xlink:href="#https://vocabulario.abcd.usp.br/pt-br/?tema=1494"/>    </member>    <member>      <roleSpec>  <topicRef xlink:href="#broader"/>      </roleSpec>      <topicRef xlink:href="#https://vocabulario.abcd.usp.br/pt-br/?tema=41748"/>    </member>  </association>  <association>    <instanceOf>      <topicRef xlink:href="#synonym"/>    </instanceOf>    <member>      <roleSpec>  <topicRef xlink:href="#non-preferred-term"/>      </roleSpec>      <topicRef xlink:href="#https://vocabulario.abcd.usp.br/pt-br/?tema=52269"/>    </member>    <member>      <roleSpec>  <topicRef xlink:href="#preferred-term"/>      </roleSpec>      <topicRef xlink:href="#https://vocabulario.abcd.usp.br/pt-br/?tema=1494"/>    </member>  </association>  <association>    <instanceOf>      <topicRef xlink:href="#synonym"/>    </instanceOf>    <member>      <roleSpec>  <topicRef xlink:href="#non-preferred-term"/>      </roleSpec>      <topicRef xlink:href="#https://vocabulario.abcd.usp.br/pt-br/?tema=52296"/>    </member>    <member>      <roleSpec>  <topicRef xlink:href="#preferred-term"/>      </roleSpec>      <topicRef xlink:href="#https://vocabulario.abcd.usp.br/pt-br/?tema=1494"/>    </member>  </association>  <association>    <instanceOf>      <topicRef xlink:href="#synonym"/>    </instanceOf>    <member>      <roleSpec>  <topicRef xlink:href="#non-preferred-term"/>      </roleSpec>      <topicRef xlink:href="#https://vocabulario.abcd.usp.br/pt-br/?tema=52365"/>    </member>    <member>      <roleSpec>  <topicRef xlink:href="#preferred-term"/>      </roleSpec>      <topicRef xlink:href="#https://vocabulario.abcd.usp.br/pt-br/?tema=1494"/>    </member>  </association>  <association>    <instanceOf>      <topicRef xlink:href="#synonym"/>    </instanceOf>    <member>      <roleSpec>  <topicRef xlink:href="#non-preferred-term"/>      </roleSpec>      <topicRef xlink:href="#https://vocabulario.abcd.usp.br/pt-br/?tema=52377"/>    </member>    <member>      <roleSpec>  <topicRef xlink:href="#preferred-term"/>      </roleSpec>      <topicRef xlink:href="#https://vocabulario.abcd.usp.br/pt-br/?tema=1494"/>    </member>  </association></topicMap>