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</topic><topic id="https://vocabulario.abcd.usp.br/pt-br/?tema=31672"><instanceOf><topicRef xlink:href="#term"/></instanceOf><baseName><baseNameString>DOENÇA DE VON WILLEBRAND</baseNameString></baseName>  <occurrence>    <instanceOf>      <topicRef xlink:href="#scope-note"/>    </instanceOf><baseName><baseNameString><![CDATA[ Grupo de transtornos hemorrágicos em que o fator de Von Willebrand está quantitativa ou qualitativamente anormal. São normalmente herdados como um traço autossômico dominante, embora haja algumas famílias raras de transmissão autossômica recessiva. Os sintomas variam dependendo da severidade e o tipo da doença, mas podem incluir tempo de sangramento prolongado, deficiência do fator VIII e adesão plaquetária deficiente.<p>Fonte: DeCS. Disponível em: https://decs.bvsalud.org<p> ]]></baseNameString></baseName>  </occurrence></topic>  <association>    <instanceOf>      <topicRef xlink:href="#broader-narrower"/>    </instanceOf>    <member>      <roleSpec>  <topicRef xlink:href="#narrower"/>      </roleSpec>      <topicRef xlink:href="#https://vocabulario.abcd.usp.br/pt-br/?tema=31672"/>    </member>    <member>      <roleSpec>  <topicRef xlink:href="#broader"/>      </roleSpec>      <topicRef xlink:href="#https://vocabulario.abcd.usp.br/pt-br/?tema=97243"/>    </member>  </association></topicMap>